To determine the apoptosis and necrosis status of the EBs formed under representative conditions, we quantified the viability of cells after 2 days of EB formation. Annexin V (an early apoptosis ...

BACKGROUND: Cardiac hypertrophy, as an important pathological change, contributes to heart failure. Recent studies indicate that the mitochondria-associated endoplasmic reticulum membranes (MAMs) play ...

The inability to generate mature cardiomyocytes has hindered the development of cell therapy for heart disease as well as the generation of cells for the in vitro study of cardiac physiology and ...

The applications illustrated in this tutorial highlight the promise of human iPSC-derived cardiomyocytes to provide a human in vitro test system with cross-platform functionality in a biologically ...

Human induced pluripotent stem cells (iPSCs) bring human biology into pre-clinical aspects of drug discovery. iPSC-derived cardiomyocytes have emerged as useful tools for detecting and predicting ...

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes represent a promising model for in vitro prediction of cardiac arrhythmias. Currently, two commercially available hiPSC-derived ...

Cardiomyocytes, or cardiac muscle cells are the main type of heart cells and act as the motor unit to drive heart contraction and relaxation. Particularly, adult human primary cardiomyocyte is a ...

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes represent a promising model for in vitro prediction of cardiac arrhythmias. Currently, two commercially available hiPSC-derived ...

Axol’s human iPSC-derived ventricular cardiomyocytes are manufactured at scale according to strict quality control standards using ISO 9001-accredited quality management systems, providing a ...

"We have several pharmaceutical customers who've validated in vitro cardiotoxicity assays using iCell Cardiomyocytes, which have correlated well with previous data from cardiotoxicity studies in ...