To verify this mechanism, researchers tested it in mice and in human tissue. When Heppner's team blocked IL-12 in cell cultures and mouse models, they could stem disease-related changes.

Given the evidence that IL-12 up-regulates IFN-γ production mainly via the STAT4 signaling pathway (Szabo et al., 2003), we evaluated the role of STAT4 signaling pathway in the development of Th2 ...

However, TLR2 signaling also induces the activation of the Ras-guanine nucleotide-releasing protein 1 (RasGRP1)–ERK1/2 signaling pathway, which exerts an inhibitory effect on TLR9-mediated IL-12 ...

More information: Shirin Schneeberger et al, Interleukin-12 signaling drives Alzheimer's disease pathology through disrupting neuronal and oligodendrocyte homeostasis, Nature Aging (2025). DOI: 10 ...

To evaluate the safety of sequentially administered recombinant (r) human (h) interleukin-12 (IL-12) and interferon alfa-2b (IFN-α-2b) in patients with advanced cancer and to determine the effects of ...

IL-12 accelerates Alzheimer’s by damaging brain cells. Blocking IL-12 may offer a new therapeutic approach, ... Sciences in Göttingen also showed how myelin structure and nerve fiber density changed ...

Interleukin-12 signaling drives Alzheimer’s disease pathology through disrupting neuronal and oligodendrocyte homeostasis. Nature Aging , 2025; DOI: 10.1038/s43587-025-00816-2 Cite This Page : ...

IL-12 is a heterodimer existing as two isoforms, IL-12p40 and IL-12p70, the latter being less abundant. It is activated via the IL-12 receptor with IL-12Rβ1 and IL-12Rβ2 chains, which are key to ...

Optimal induction of IFN-γ by IL-12 occurred after an IV dose of 250 ng/kg. Patient PBMCs exhibited increased levels of STAT1 after IL-12 administration. The peak level of IFN-γ achieved with IL-12 ...

Researchers from Charité – Universitätsmedizin Berlin and the Max Delbrück Center have detailed the precise mechanism through which the inflammatory signaling molecule IL-12 contributes to ...