Obstructive sleep apnoea (OSA) is recognised to be a potent risk factor for hypertension, coronary heart disease, strokes and heart failure with a reduced ejection fraction. However, the association ...

Photodynamic therapy (PDT), a noninvasive cancer therapeutic method triggered by light, would lead to severe tumor hypoxia after treatment. Utilizing a hypoxia-activated prodrug, AQ4N, which only ...

Exposure for rodents to chronic intermittent hypoxia is also used to mimic the cyclic pattern of hypoxemia observed in patients experiencing obstructive sleep apnea 143,144 —a condition complicated by ...

Background It is unknown whether lesions in human TB are hypoxic or whether this influences disease pathology. Human TB is characterised by extensive lung destruction driven by host matrix ...

Abstract. Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age. Chronic mild hypoxia (CMH; 8% O 2) triggers transient blood-brain barrier (BBB) disruption, an ...

The system could efficiently alleviate hypoxia in tumor environments for up to 7 days, meeting the “once injection, repeat irradiation” strategy and enhanced PDT efficacy. Besides, the generated ...

However, the mechanisms underlying neutrophil reprogramming remain elusive. In this study, we report that the immunosuppressive ability of brain tumor–infiltrating neutrophils was restricted to a ...

Endothelin-1 (ET-1) mediates hypoxia-mediated pulmonary vascular remodeling (HPVR), and endothelin-A receptor (ET-AR) blockade prevents HPVR in newborn mice. Our objective was to determine ...

Hypoxia-inducible factor-2α (HIF-2α) inhibitor belzutifan in von Hippel-Lindau (VHL) disease–associated neoplasms: 5-year follow-up of the phase 2 LITESPARK-004 study. Authors : Vivek Narayan , Eric ...

Hypoxia-responsive CEA CAR-T cells therapy for relapsed or refractory non-small cell lung cancer: A single-arm, open-label, phase I trial. Shuang Wei, Jiaqi Guo, Xueli Bai, Cheng Qian, Yicheng Zhang, ...