W. A. Bone and R. V. Wheeler first studied the combustion of methane and were led to the view that oxidation takes place through successive stages of hydroxylation of the hydrocarbon. In view of ...

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, NHC Key Laboratory of Biosynthesis of Natural Products, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, ...

Kim V. Narry, director of the Center for RNA Research at the Institute for Basic Science (IBS), has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics.

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These findings are considered important due to the broad utility of the unified framework and network analysis capable of revealing communities of key residues that go beyond the residue-pair concept.

HIFα proteins are degraded because of hydroxylation, ubiquitination, and their targeting through the proteasome ... additional increase in the pool of these proteins after 1 day of hypoxia (Fig. 3b), ...

Mutations cause ECM dysfunction by combinations of two mechanisms. First, secretion of the mutated ECM components can be reduced by mutations affecting synthesis or by structural mutations causing ...

Based on the known mechanisms of primordial follicle activation, primordial follicle in vitro activation (IVA) technique has been clinically developed. IVA can help patients with premature ovarian ...

Here, we show hypoxia is a physiological trigger for this truncation, which occurs through a two-part mechanism: (1) increased targeting of SM to the proteasome via stabilization of the E3 ubiquitin ...

Not only have the basic clinical and genetic pillars of classical OI been refined, but several new forms of monogenic osteoporosis have also been identified that have pinpointed novel molecular ...