This study presents an important finding on the role of GATA4 in aging and OA-associated cartilage pathology. The evidence supporting the conclusions is compelling, with rigorous in vitro and in vivo ...

Vaccines work by imitating an infection to teach the body how to recognize and defend itself from disease without experiencing the dangers of an actual infection, according to the CDC. "They do so ...

With a mission that primarily encompasses engineering and construction for the U.S. military and allied nations in the Middle ...

骨关节炎（OA）和类风湿关节炎（RA）缺乏有效治疗手段，现有疗法或仅缓解症状或存在免疫抑制等局限。本研究开发靶向基质金属蛋白酶 13（MMP13）的 siRNA 共轭物，通过 “拉链” 修饰增强稳定性，结合白蛋白实现关节靶向。在小鼠和豚鼠模型中，单次注射即可 ...

Smith et al. use clinical development screen and whole genome siRNA-reverse genetics phenotypic screen to identify ROCK2, as a modulator of cilia formation and function via its effects on actin ...

But the treatments Kennedy supports generally do not help kids or adults get rid ... in the airways of people with asthma. “These drugs work by suppressing the immune system,” Hazra says.

Innovative delivery techniques, including high-tech nanoparticles and electroporationdevices, may convey more gene therapies into the clinic.

“Smaller siRNA and ASO nucleic acid therapeutics can be chemically synthesised with modifications that impart increased nuclease stability and do not require encapsulation into nanoparticle ...

Note that if you use your car for work purposes, you may need a commercial car insurance policy rather than a personal one. If you sell your car or switch insurance providers, make sure you cancel ...

Once released, the RNA is free to do its job ... that it used to deliver its other siRNA therapies subcutaneously. For a brief time, new work on LNPs fell out of favor—that is, until new ...

With so many people swearing by vision boards, affirmations, or the all-mighty law of attraction to accomplish their goals, it’s fair to wonder: Wait…does manifesting work? Maybe you’ve ...