During meiosis, at least one crossover is selectively generated per pair of homologous ... recombination, particularly in XY chromosomes that share a tiny region of homology (i.e., the pseudoautosomal ...

Copy number variants (CNVs) arise by homologous recombination (HR ... there is some probability that genetic change such as copy number variation will result. These mechanisms that do not use ...

In four of six cases, the recombination resulting in the duplication occurred between homologous chromosomes (interchromosomal). In one duplication patient (1353), the duplication was derived from ...

Due to its high efficiency, versatility, and simplicity, the CRISPR/Cas system has become one of the most popular gene editing technologies. In this review, we briefly introduce the CRISPR/Cas systems ...

Identification of BRCA mutations and/or homologous recombination deficiency (HRD) is critical for selecting patients for ... In general, HRD assays have three main categories: germline or somatic ...

Synthego, a leading genome engineering solutions company, today announced the launch of the Gene Knockout Kit v2. This is the only product that leverages a novel ...

Learn about our Editorial Policies. Functional studies of genes can be greatly aided by the use of haploid cell lines—those that have just one of each chromosome, rather than a pair—because the ...