Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

生命科学Life science2025年3月11日，中国科学院大连化学物理研究所周雍进研究员团队在Cell Press细胞出版社期刊Trends in Biotechnology上发表题为“Inducible regulating ...

Elliott B, Richardson C, Winderbaum J, Nickoloff JA, Jasin M. 1998 Gene conversion tracts from double-strand break repair in mammalian cells in mammalian cells. Mol Cell Biol. 1998;18:93-101. Johnson ...

It is thought that these proteins play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside in pairs ...

Imunon has announced the alignment of the FDA with the Phase III OVATION 3 trial of IMNN-001 for ovarian cancer protocol.

"When DNA damaged by radiation therapy was repaired by a method called homologous recombination, cancer cells died during the ...

Different genomic alterations in DNA damage repair (DDR) pathways occur in 20% to 25% of advanced prostate cancer, including homologous recombination repair (HRR) gene alterations. Identifying the ...