Unfortunately, regenerative potential of the adult heart is limited. The Hippo pathway is a recently identified signaling cascade that plays an evolutionarily conserved role in organ size control by ...

SAN MATEO, Calif., March 12, 2025 /PRNewswire/ -- Vivace Therapeutics, Inc., a small molecule discovery and development company developing first-in-class cancer therapies targeting the Hippo pathway, ...

We identified three ubiquitin ligases – RNF146, TRAF3, and PHF5A – as potential negative regulators for the Hippo pathway from the primary screen using the luciferase reporter (Supplemental Table 3 ...

Inhibition of MAP4K kinases reduced Hippo pathway activity. HEK293A cells were treated with GNE‐495 (inhibitor of MAP4K kinases) at 0, 1, 5, or 10 μM for 24 h. Phosphorylation of LATS1 (HM), NF2 (S13, ...

The Hippo pathway is mainly composed of mammalian serine/threonine (Ste20)like kinases 1/2 (MST1/2), large tumor suppressor 1/2 (LATS1/2), and transcriptional coactivator Yes-associated protein (YAP), ...

College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, China The Hippo signaling pathway is a novel tumor suppressor pathway, initially found in Drosophila. Recent studies have ...

Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China ...

They discovered that during development, when progenitor heart cells progressively differentiate into various cell types, the Hippo pathway is essential to coordinate the development of these cell ...