I discovered a conserved function for the mitochondrial protein unfoldase ClpX as an activator of the initial enzyme in heme biosynthesis, ALA synthase. ClpX performs an unusually targeted, partial ...

While the genes and enzymes involved in natural product biosynthesis are often known, a comprehensive understanding of the associated enzymology is still lacking. This gap presents a significant ...

Bitopertin is the lead product candidate in the company’s heme biosynthesis modulation portfolio. Treatment with bitopertin resulted in statistically significant reductions in toxic metabolite ...