大脑结构变化与精神分裂症密切相关，灰质结构可能是抗精神病治疗效果的潜在指标。传统单变量分析虽已识别出精神分裂症患者的大脑结构异常，但难以应用于个体化治疗决策。机器学习在整合个体特征方面潜力巨大，已有研究利用其预测精神分裂症治疗反应，但多存在局限性，且综合利用灰质体积（GMV）、皮质厚度（Ct）和卷曲指数（GI）等指标的研究较少。此外，抗精神病药物治疗会使患者大脑发生变化，研究首发未用药精神分裂症患 ...

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