更令人振奋的是，采用UNG抑制剂或腺相关病毒(adeno-associated virus, AAV)载体递送尿嘧啶-DNA糖基化酶抑制剂(UGI)的治疗方案，成功将野生型HSV-1感染小鼠从死亡边缘拉回。 这些发现不仅绘制出HSV-1与宿主APOBEC1博弈的分子图谱，更开辟了对抗病毒性脑炎的新战线——靶 ...

When mice received this AAV-UGI vector before exposure to HSV-1, they were far more likely to survive. However, when the mice lacking APOBEC1 received this treatment, the protective effect ...

When mice received this AAV-UGI vector before exposure to HSV-1, they were far more likely to survive. However, when the mice lacking APOBEC1 received this treatment, the protective effect ...

这篇综述系统梳理了眼科基因治疗的最新进展，重点探讨了病毒/非病毒载体（AAV/CRISPR-Cas9）在遗传性视网膜疾病（IRDs ...

People diagnosed with HSV-1 infection had a higher risk of a subsequent Alzheimer's diagnosis. Antiherpetic drugs reduced Alzheimer's risk in those diagnosed with HSV-1. The findings apply only to ...

Infections caused by herpes simplex virus type 1 (HSV-1) can lead to HSV-1 encephalitis-a rare but deadly condition that inflames the brain. Despite decades of research, treatment options for this ...

Infection with herpes simplex virus type 1 (HSV-1), the virus that causes cold sores, is associated with the development of Alzheimer’s disease – that’s the conclusion of a new case-control ...

A new study has found the herpes simplex virus type 1 (HSV-1), which causes cold sores, may be linked to the development of Alzheimer's disease. This idea is not entirely new. Previous research ...

More information: Association between herpes simplex virus type 1 and the risk of Alzheimer's disease: a retrospective case– control study, BMJ Open (2025). DOI: 10.1136/bmjopen-2024-093946 ...

Herpes simplex virus 1 (HSV-1) infection is associated with an increased risk of developing Alzheimer’s disease (AD), but treating the viral infection may offer protection, a new study found.

The Centers for Disease Control and Prevention (CDC) estimates that about 45 million people in the United States have genital HSV, with up to a half-million new cases identified each year.

According to the World Health Organization, about 3.8 billion people under age 50 have HSV-1. Around 520 million people ages 15 to 49 have HSV-2. According to the World Health Organization ...