Purpose: Clinical trials evaluating the effectiveness of therapy with hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitors for reducing elevated C-reactive protein (CRP) levels and ...

The present experiments were designed to test the hypothesis that inhibition of cholesterol biosynthesis by the potent HMG-CoA reductase inhibitor atorvastatin modulates exogenous TRL metabolism in ...

Background and Purpose— Statins reduce the risk of stroke recurrence, but the benefits of statins in improving outcome of acute stroke patients have not been well explored. Methods— We assessed ...

† Department of Chemistry and Biochemistry, Notre Dame University, Notre Dame, Indiana 46556, United States ‡ Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, ...

The CV benefit of statins can be partly explained by their ability to inhibit of HMG-CoA reductase, which subsequently lowers cholesterol and decreases the formation of mevalonate. However ...

A lifesaving drug for millionsCholesterol disorders affect millions of people globally and are among the leading risk factors ...

本研究揭示了缺氧条件下转录因子Srebf和Runx3通过调控HMG-CoA还原酶（Hmgcr）表达影响胆固醇代谢的新机制。通过自发高血压大鼠（SHR）模型和体外实验，发现缺氧诱导的Hif-1α通过差异调控Srebf（抑制）和Runx3（激活）结合Hmgcr启动子区域，为心血管疾病（CVDs ...

Tang, L. , Yang, W. and Wang, Q. (2025) Case Analysis and Management Strategies of Glucocorticoid-Induced Metabolic Syndrome during Pregnancy. Journal of Biosciences and Medicines, 13, 39-45. doi: ...

本研究针对胶质瘤治疗难题，揭示了miR-139-5p通过靶向抑制HMGCR（3-羟基-3-甲基戊二酰辅酶A还原酶）表达，下调GPX4（谷胱甘肽过氧化物酶4）蛋白合成，激活铁死亡（ferroptosis）的新机制。研究人员发现miR-139-5p与辛伐他汀（SIM）联用可协同抑制胆固醇合成通路，为 ...

如需其他Elisa试剂盒说明书及报价，可来电咨询我公司。 小鼠HMG-CoA还原酶(HMGR)Elisa Kit，抗血清的制备方法： 有了质量好的抗原，还必须选择适当的免疫途径，才能产生质量好（特异性强和效价高）的抗体。 作免疫用的动物有哺乳类和禽类，主要为羊、马、家兔 ...

These mutations prevent the regulated transport of UBIAD1 from the endoplasmic reticulum (ER) to the Golgi, which leads to inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) ...