研究发现了HIV-1病毒如何将核苷酸导入其核心，从而为DNA合成提供燃料的机制，而DNA合成是其复制的关键步骤。超级计算机分子动力学模拟有助于测试易位和自由能计算。由nsf资助的XSEDE通过TACC stampede和PSC桥支持的研究。HIV-1衣壳的研究为治疗开发提供了新的药物靶点，如改进的抗逆转录病毒药物。

本研究展示了PROTAC在靶向降解HIV-1 Nef蛋白方面的出色效果。通过靶向降解Nef，PROTAC不仅恢复了T细胞表面MHC-I和CD4的表达，还显著抑制了HIV-1的复制 ...

Better understanding of HIV biology, virus-host interactions and mechanisms of an efficient immune response advance efforts for effective vaccines and immunotherapies. Since its discovery in 1983 ...

The aim of this study was to learn more about the role of the HIV-related chemokine–chemokine receptor axes in human hematopoiesis. To address this issue we phenotyped 35 selected hematopoietic ...

"When HIV infects the body, certain immune cells called CD4 + T cells respond by increasing levels of two microRNAs—miR-6727-3p and miR-4722-3p—that likely help fight the virus," said Caputi ...

And the long, thin structures that the HIV particles are riding on are filopodia (4) – filaments in some kinds of cells, including nerve cells. Biology in the background. HIV is a virus that mainly ...

This card activity encourages students to explore the characteristics of living things and helps them determine what qualifies as life. After reviewing the HIV life cycle, students can use this ...

A supercharged HIV vaccine could offer strong protection with just one injection, a study in mice has indicated. Developed by researchers from the Massachusetts Institute of Technology (MIT) and the ...

There are many diseases that mosquitoes can transmit, but HIV isn't one of them. Here's why, and what viruses you do need to watch out for depending on where you live.

HIV using 'secret handshake' to get in The HIV capsid, however, has evolved to interact with the barrier proteins in the same way as the host's chaperone proteins.

A new twice-yearly shot could be a "game changer" in the fight against AIDS, but experts' hopes have dimmed because of the ...