To cope with hypoxia, tumor cells have developed a number of adaptive mechanisms mediated by hypoxia-inducible factor 1 (HIF-1) to promote angiogenesis and cell survival. Due to significant roles of ...

As the name implies, HIF (hypoxia-inducible factor)-α family members are pivotal transcription factors that orchestrate adaptive responses under low oxygen conditions. Under normoxia, the HIFα protein ...

Cellular hypoxia triggers a multifaceted adaptive response that is primarily mediated by the heterodimeric transcription factor hypoxia-inducible factor 1 (HIF). Under normoxic conditions, the α ...

The progressive worsening of disc degeneration and related nonspecific back pain are prominent clinical issues that cause a tremendous economic burden. Activation of reactive oxygen species (ROS) ...

Longtime UW professor Ed Lazowska said there is usually a winner and one or two honorable mentions, and that in the U.S. alone there are more than 2,000 computer science PhD dissertations annually.

在vhl缺失的ccrcc细胞中，dmf通过hif-1α而非hif-2α上调pd-l1。 HIF-1α抑制剂YC-1可阻断该效应，而HIF-2α抑制剂TC-S 7009无效。 siRNA敲低实验进一步验证HIF-1α的关键作用。

Last week, the House passed a sweeping budget bill, the centerpiece of President Donald Trump's domestic agenda.The final vote was 215 to 214, just one vote shy of failure, with all but two ...

Delavan sophomore Corie Green won the Class 1A 800 run in 1:55.46. Princeton senior Ian Morris won the 2A discus in 53.58 meters. Bureau Valley senior Landon Hulsing won the 1A discus in 57.19 meters.

Hypoxia-inducible factor-2α (HIF-2α) inhibitor belzutifan in von Hippel-Lindau (VHL) disease–associated neoplasms: 5-year follow-up of the phase 2 LITESPARK-004 study. Authors : Vivek Narayan , Eric ...

Landscape of genomic alterations in genes implicated in the regulation of hypoxia inducible factor (HIF) signaling: A pooled analysis of two pan-cancer cohorts.. JCO 43 , 3143-3143 (2025). DOI: ...