Ischemic stroke may promote neuronal glycolysis, leading to lactate accumulation in brain tissue. This accumulation of lactate accumulation may heighten neuronal excitability by upregulating protein ...

近日，一篇发表在国际杂志Frontiers of Medicine上题为“ING5 inhibits aerobic glycolysis of lung cancer ... 了ING5的过表达会显著增加PDK1 Y163位点的磷酸化，进而 ...

This led to a decrease in PDHA1 S293 phosphorylation and an increase in PDH enzyme activity, promoting oxidative phosphorylation and reducing glycolysis. The clinical relevance of PDK1 Y163 ...

Targets of each inhibitor are diagrammed in Figure 2A. GSK233 inhibits phosphoinositide-dependent kinase-1 (PDK1), the kinase that activates Akt via phosphorylation of threonine 308 (T308), whereas ...