The slices were recovered in a chamber while submerged in artificial cerebrospinal fluid buffer (aCSF) held at 32°C, containing (in mM): 125 NaCl, 10 d ‐glucose, 25 NaHCO 3, 2.5 KCl, 1.25 NaH 2 PO 4, ...

Bitopertin is an investigational, clinical-stage, orally administered inhibitor of glycine transporter 1 (GlyT1) that is designed to modulate heme biosynthesis ... Bitopertin has been studied in ...

Similarly, the universities portfolio in Preclinical comprises 2 molecule. Sodium And Chloride Dependent Glycine Transporter 1 overview. Sodium- and chloride-dependent glycine transporter 1 is a ...

2003), drug development has primarily focused on inhibitors specific for glycine transporter 1 (GlyT1) to avoid blockade of glycine transporter 2 (GlyT2) (see Harvey and Yee, 2013). Indeed, there is a ...

Discipline of Pharmacology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales 2006, Australia ...

Molecular and Cellular Biomedicine Theme, School of Medical Sciences, University of Sydney, Sydney, NSW 2006, Australia ...

Transporter Biology Group, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia Neurotransmitter sodium symporters (NSS) are a subfamily of SLC6 ...

The designation is based on results from a phase 2 trial that evaluated the efficacy ... an investigational glycine transporter-1 (GlyT1) inhibitor, for the treatment of cognitive impairment ...

This could be done using inhibitors targeting Glycine Transporter 1 (GlyT1), a protein that sits in neuronal cell membranes and is responsible for the uptake of glycine into neurons. However, the ...