Objective In systemic lupus erythematosus (SLE), disease activity and glucocorticoid (GC) exposure are known to contribute to irreversible organ damage. We aimed to examine the association between GC ...

Introduction Antineutrophil cytoplasm antibody-associated vasculitis (AAV) is a form of systemic vasculitis. The current standard induction therapy with the ...

In addition, PCSK9 has direct effects on thrombogenesis and atherosclerotic plaque formation. We aimed to investigate (1) the impact of glucocorticoids and biological disease-modifying antirheumatic ...

1 Dubowitz Neuromuscular Centre, UCL Institute of Child Health and Great Ormond Street Hospital Foundation Trust, London, UK 2 Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of ...

1 These cardiometabolic and immune impairments are common comorbidities of Cushing's syndrome, a condition characterised by excessive exposure to endogenous glucocorticoids. In patients with Cushing's ...

Introduction Glucocorticoids are still a mainstream of rheumatoid arthritis (RA) treatment. Reducing glucocorticoids should be attempted in all patients. However, choosing the right tapering strategy ...

Department of Obstetrics, Guangming District People’s Hospital, Shenzhen, China. A 36-year-old primigravida (G1P0) was admitted on June 15, 2021, at 30 + 6 weeks of gestation due to “vaginal bleeding ...

Glucocorticoid-remediable aldosteronism (GRA) is a monogenic form of human hypertension that predisposes to cerebral hemorrhage. As a result of a chimeric gene duplication, aldosterone is ectopically ...

The reported tool, DIPx, could be of use for personalized drug synergy prediction and exploring the activated pathways related to the effects of drug combinations. Targeted monotherapies for cancer ...

“Building from the tremendous success of our PreK–12 and Higher Education Pathways, this new pathway allows us to expand our innovative online pedagogies on a global scale, providing HGSE’s signature ...

As IKZF1 and BTG1 deletions are associated with a worse outcome in B-ALL, this study aimed to address whether they synergistically promote glucocorticoid resistance. Methods: Small interfering RNA was ...

Background and aims: Acute radiation-induced intestinal injury (ARII) usually occurs after pelvic radiotherapy. Glucocorticoids are potentially effective for the treatment of ARII due to their ...