Researchers have identified a molecular pathway responsible for the spread of glioblastoma to surrounding tissue in the brain, as well as an existing drug that curbed tumor growth in animal models.

Uncover the mechanisms behind brain tumour spread. New research sheds light on glioblastoma infiltration of normal brain tissue.

New pathway for potential glioblastoma treatment. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2019 / 08 / 190821163812.htm. Texas A&M University.

Their analyses identified the PTP4A2-ROBO1 pathway which is involved in axonal guidance—a signalling axis that helps establish normal brain architecture —that can become overrun by cancer cells.

To discover the pathway cancer cells use to infiltrate the brain, researchers used large-scale gene editing technology to compare gene dependencies in glioblastoma when it was initially diagnosed ...

“In glioblastoma, we believe that the tumor hijacks this signalling pathway and uses it to invade and infiltrate the brain,” says co-senior author Sheila Singh, professor with McMaster’s Department of ...

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of ...

Glioblastoma has been deadly and hard to treat, but researchers say they’ve made progress with bivalent CAR T-cell therapy delivered directly into the brain.

Probing further, Dr. Chen's team discovered that the epigenetic factor determining whether or not glioblastoma cells can proliferate indefinitely as cancer stem cells is their relative abundance ...