Age associated with P-tau181, NfL, and GFAP; significant association seen for APOE ε4 status with P-tau181, GFAP ...

年龄相关性听力损失（ARHL）问题日益凸显，ApoE-ε4 基因与 ARHL 关联备受关注。研究人员以 ApoEε4/ε4（APOE4）和 ApoEε3/ε3（APOE3）小鼠为对象，探究 APOE4 在螺旋神经节神经元（SGNs）轴突脱髓鞘中的作用。结果发现 APOE4 促进脱髓鞘，且巨噬细胞脂质自噬受损。

研究团队采用单分子阵列技术(Simoa)这一超灵敏检测方法，对113名参与者(认知正常53人、MCI 45人、AD 15人)的血浆样本进行GFAP、NfL和p-tau 181 定量分析，同时完成APOE基因分型和神经心理学评估。技术路线的严谨设计保障了数据可靠性：血浆样本在采集后2小时内完成 ...

Topline results were announced from a phase 3 trial evaluating valiltramiprosate (ALZ-801) in apolipoprotein ε4 allele (APOE4) carriers with early Alzheimer disease (AD). Valiltramiprosate is an ...

The mechanism by which neurogenesis regulates the profile of neurons and glia in the hippocampal formation is not known. Further, the effect of neurogenesis on neuronal vulnerability characterizing ...

Patients with only one or no copy of ApoE4 are less likely to experience so-called ARIA side effects, like brain swelling and bleeding, associated with amyloid-targeting drugs, than people with ...

The peel-off lip product she used was Sacheu's Lip Stain. She applied it as a liner—thanks to its ultra-precise applicator—but it works just as beautifully all over the mouth too. The formula ...