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GSPT2 (G1 to S phase transition protein 2) has emerged as a critical regulator of the cell cycle and has garnered increased attention for its role in tumor biology in recent years. This review ...

The G1 phase of the cell cycle serves the purpose of preparing the cell for replication. During this phase, the cell increases the number of organelles, synthesizes proteins and enzymes needed for DNA ...

Each interphase is divided into G1, S, and G2. G1 phase. This is the first stage of interphase, during which the cell grows and organelles begin to ... The “G2 phase” is the second stage of the growth ...

The cell cycle is a complex process that involves the growth and division of a cell. It is divided into four phases: G1, S, G2, and M. During each phase, the cell undergoes a series of events that ...

Here, we show that widespread and temporally controlled mRNA decay acts as an additional mechanism for gene expression regulation during the cell cycle in human cells. We find that two waves of mRNA ...

Thus, key cell cycle transitions occur only when sufficient growth has occurred. A particularly important point at which cell growth controls cell cycle progression is at the end of G1 phase, when ...

Although MTAs characteristically induce death in mitosis, microtubule destabilizing agents such as vincristine also induce death directly in G1 phase in primary acute lymphoblastic leukemia (ALL) ...

The prevailing dogma is that renewed mitogenic signaling is essential to traverse G1 phase of the cell cycle after each division. B lymphocytes undergo multiple mitotic divisions, termed clonal ...

The cell cycle contains 4 stages; Gap 1 (G1) phase, synthesis (S) phase, gap 2 (G2) phase and mitosis (M) phase. For most human cells, a single cell cycle takes approximately 24 hours. However ...