For the past five years, researchers at Leipzig University have been working on fundamentally new methods for selectively ...

The scientists at Leipzig University, together with their collaborators at Purdue University (US), have published a summary ...

February 1, 2012 (Vol. 32, No. 3). Tocopherol Modification Improves Product Purification and Aids Delivery into Cells. The use of oligonucleotides as therapeutic agents is of great interest ...

Ansa’s proprietary enzymatic oligonucleotide synthesis technology is based on its patented Polymerase-nucleotide Conjugate reagents that can rapidly extend a DNA molecule by one base at a time.

There are plenty of companies making everything from short DNA fragments (called “oligos”) ... Phosphoramidite chemistry, developed in the 1980s, is the standard method for DNA oligo synthesis.

One method of achieving this is the use of a cleavable disulphide bridge between the delivery agent and the oligonucleotide. However, when used in vivo there is the potential for toxic effects ...