Limited penetration depth into tumor tissues continues to hinder the development of nanotherapeutics for cancer treatment. A ...

1 Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China 2 Hunan Key Laboratory of Non-resolving Inflammation and Cancer, Changsha, China Background: ...

Interestingly, homeobox A10 (HOXA10), an upstream positive regulator of RUNX2 isoform II, is required for the inhibition of ferroptosis and apoptosis through the RUNX2 isoform II/PRDX2 pathway.

Conversely, treatment of a cancer cell line with the ferroptosis inducer RSL3 resulted in initial oxidation of membrane lipids predominantly in lysosomes. Together, these findings indicated that ...

A novel self-propelled ferroptosis nanoinducer developed by Southern Medical University was able to achieve deeper ...

Researchers at Southern Medical University developed a self-propelled ferroptosis nanoinducer that can reach deeper into tumor tissues. This led to better anti-cancer effects while maintaining good ...

Scientists have discovered tumors can tap a nontraditional pathway to acquire lipoproteins—molecules that transport fat in ...

French researchers have developed phospholipid degraders that trigger iron-catalyzed cell death in aggressive cancers like ...

Regulated cell death is a widely attractive subject among the topics of cancer therapy and has gained some advances for discovery of targeted anticancer drugs. In the past decade, nonapoptotic ...