通过分析铁调节激素（Hepcidin）和转运蛋白（Ferroportin）的调控机制，提出铁螯合剂（Iron chelators）可能成为限制病毒感染的潜在治疗策略，为抗病毒研究提供了新视角。 铁与病毒：一场微观世界的资源争夺战 铁（Iron）是生命体不可或缺的微量元素，却在病毒与 ...

Systemic iron regulation. (1) Heme iron is absorbed on the luminal side of duodenal enterocytes. Within the enterocyte, heme is broken down by HO-1 and iron can either be stored as ferritin or enter ...

cGraduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, 4050-343 Porto, Portugal dTranslational Lung Research Center Heidelberg (TLRC) ...

Alternatively, iron is exported to plasma from the ferroportin (FPN) by the basolateral membrane according to the needs [6] . Tissue and circulating iron levels are controlled by several genes such as ...

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 110, Taiwan Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical ...

A central regulatory mechanism of iron homeostasis in humans involves ferroportin (FPN), the sole cellular iron exporter, and the peptide hormone hepcidin, which inhibits Fe 2+ transport and induces ...

Introduction: Ferroportin (FPN), the only identified eukaryotic iron efflux channel, plays an important role in iron homeostasis and is downregulated in many cancers. To determine if iron related ...

The authors present a manuscript aiming to understand how systemic iron overload counteracts the hypoferremic effects of a specific inflammatory stimulus, specifically focused on the role of ...

We now show that hinokitiol is capable of redistributing iron systemically, which in turn restores iron homeostasis in ferroportin-deficient mice and in primary macrophages derived from patients with ...

Hepcidin is a hormone secreted in response to iron loading and inflammation. Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma. We ...