Do the findings shut the door on approaches to increase fatty acid oxidation ... 1 find no benefit from quelling the activity of acetyl-CoA carboxylase-2 (ACC-2), an enzyme downstream of AMPK ...

During beta-oxidation, fatty acid molecules are broken down by removing two-carbon units from the carboxyl end of a fatty acid molecule to produce acetyl-CoA.

The absence of PanK4 led to a significant increase in acetyl-CoA, which disrupted the regulation of fatty acid oxidation and glucose metabolism. During training studies with mice specifically ...

The absence of PanK4 led to a significant increase in acetyl-CoA, which impaired the regulation of fatty acid oxidation and glucose metabolism. The latter manifested itself in the muscle-specific ...