The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively ...

In a recent study published in Nature, researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Farnesoid X receptor is a member of the ligand-activated nuclear hormone receptor superfamily. It functions as heterodimer with retinoid X receptor and binds genomic DNA of the target genes ...

The farnesoid-X receptor (FXR), also known as the chief regulator of bile acid metabolism, is thought to play a role in some hepatobiliary and gastrointestinal disorders. A recent study has ...

TERN-101 is a potent, non-bile acid farnesoid X receptor (FXR) agonist. FXR activation has been shown to prevent the progression from histological liver fibrosis to NASH.

The farnesoid-X receptor (FXR), also known as the chief regulator of bile acid metabolism, is thought to play a role in some hepatobiliary and gastrointestinal disorders. In a study published in ...

The expression and activity of Cystathionase is reduced in rodent models of liver injury, leading to hyper-homocysteinemia and impaired generation of hydrogen sulphide, two factors that contribute ...

Please provide your email address to receive an email when new articles are posted on . FXR314-treated patients achieved up to 22.8% reduction in liver fat content at 16 weeks vs. 6.1% with ...