Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling ...

Find more information on the Altmetric Attention Score and how the score is calculated. Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the ...

Biological responses to progesterone are mediated by both genomic (e.g. progesterone receptor acts through specific progesterone response elements within the promoter region of target genes) and ...

In this phase 3, open-label, randomized trial, we enrolled patients with ER-positive, human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer who had received one ...

The "key?" A molecule that targets a specific protein called the kappa opioid receptor (KOR). Opioids are commonly known as powerful painkillers with strong psychoactive effects. They increase ...

Associate Professor Sebastian Furness from the UQ School of Biomedical Sciences said the team discovered the body's receptor for ghrelin had a critical role in the normal function of the spinal ...

The object, known as ASKAP J1832-0911, emits pulses of radio waves and X-rays for two minutes every 44 minutes. The paper, "Detection of X-ray Emission from a Bright Long-Period Radio Transient ...

We thank Bruce Vallance for their gift of Il18 −/− mice. NJW was supported by both an Ontario Graduate Scholarship and Canadian Graduate Scholarship, and this project was funded by Grants from the ...