Objective The gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling ...

Recent advances in cardiovascular research increasingly recognize the gut microbiome as a pivotal factor influencing cardiovascular disease (CVD) pathogene | Drug Discovery And Development ...

Here the authors show that the transcriptional coactivator YAP exerts a repressor role on Farnesoid X receptor (Fxr), the master transcriptional regulator of BA synthesis, contributing to the ...

Tertiary sulfonamides were identified in a HTS as dual liver X receptor (LXR, NR1H2, and NR1H3) ligands, and the binding affinity of the series was increased through iterative analogue synthesis. A ...

引言在我们的身体里，肝脏是一个重要的“化工厂”，默默执行着上百种关键任务。然而，现代生活方式正让这个勤劳的器官不堪重负。脂肪肝，正以前所未有的速度席卷全球。当脂肪在肝脏中过度堆积，并引发炎症和损伤时，它就演变成一种更具威胁性的疾病——代谢功能障碍相关 ...

Elon Musk's X is launching XChat in beta with encryption, vanishing messages, and file sharing. XChat aims to enhance privacy on X, aligning with Musk's vision for an everything app. XChat's ...

Tesla billionaire Elon Musk has become a close advisor to U.S. president Donald Trump alongside ...More running his companies that include the X social network formerly known as Twitter.. Getty ...

Associate Professor Sebastian Furness from the UQ School of Biomedical Sciences said the team discovered the body's receptor for ghrelin had a critical role in the normal function of the spinal ...

Astronomers have discovered a mysterious new object in our Milky Way, which is emitting X-rays and radio waves at the same time. Latest U.S.

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

The "key?" A molecule that targets a specific protein called the kappa opioid receptor (KOR). Opioids are commonly known as powerful painkillers with strong psychoactive effects. They increase ...