The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in intestinal antibacterial defence and barrier function. The aim of this study was to investigate the therapeutic potential ...

School of Basic Medical Sciences, Guangzhou Νational Laboratory, Guangzhou Medical University, Guangzhou 511436, China ...

The Swiss pharma said it is to begin a phase IIb trial of one of its Farnesoid X receptor (FXR) agonists in combination with Allergan’s cenicriviroc in NASH. A group of around half a dozen ...

It is administered through oral route. It acts by targeting farnesoid X receptor (FXR). The drug candidate was under development for primary sclerosing cholangitis in U.S. Cascade Pharmaceuticals is a ...

Preclinical studies suggest that bile acids can contribute to development of NAFL and NASH by altering nuclear bile acid receptor farnesoid X receptor (FXR) signalling.69 70 The primary bile acid ...

Fibroblast growth factors (FGFs) signal through FGF receptor tyrosine kinases to regulate a wide range of biological processes during development and adulthood. FGF receptors (FGFRs) are involved ...

The orphan nuclear receptor NR0B2 was reported to suppress liver cancer development in a mouse model, and its expression levels were reduced in liver cancer tissues and cell lines due to ...

Nuclear hormone receptor NR4A1 is also required for the effect of isoalloLCA on Treg cells. In addition, a distinct Treg population expressing the transcriptional factor RORγ is also induced in the ...

Angiopep-2 (Ang2) is an oligopeptide that can target the blood–brain barrier. Through single-cell sequencing and immunofluorescence experiments, we confirmed that the expression of LRP-1, the targeted ...

The biggest stories of the day delivered to your inbox.

Gut microbes, the trillions of bacteria present in our digestive system, have an important role in helping us digest food and absorb essential nutrients. These microbes interact with the body in ...