此研究通过对尿路上皮癌中ecDNA的系统解析，揭示了其在驱动多灶性肿瘤演进和异质性形成中的关键作用，并证实了其在肿瘤发生早期即参与调控。该项成果在染色体外环状DNA（ecDNA）研究领域取得了突破性进展，随即引起了国内外媒体的高度关注。研究论文不仅在 ...

At the heart of every thriving alumni network are individuals who go above and beyond to give back. Each April, UC San Diego ...

The incidence of Human Papillomavirus (HPV)–associated oropharyngeal cancers—tumors of the back of the mouth and throat—is ...

The researchers analyzed changes to gene expression in ecDNA formed by HPV and human DNA hybridization in oropharyngeal tumor ...

23andMe, the company whose mail-in self-testing kits became synonymous with DNA testing, is filing for bankruptcy. Anne Wojcicki, who co-founded 23andMe in 2006, is stepping down as CEO as the ...

The American doctor has revealed that enigmatic DNA circles are present in more than half of patients with highly aggressive ...

Beyond actionable findings, the study also described how Arima’s technology offers deep insights into tumor biology by detecting complex genomic rearrangements such chromothripsis and extrachromosomal ...

THE mystery of what killed King Tutankhamun may finally be solved — after scientists unearthed groundbreaking DNA evidence. The young pharaoh's untimely death at just 18 has baffled experts for ...

Extrachromosomal DNAs (ecDNAs) encode oncogenic driver proteins, regulatory elements, immunomodulators, and genes of yet-unknown oncogenicity (Panel A). They exist as circular pieces of DNA in the ...

Then, his sister took a DNA test, and those suspicions turned to truth. He had been mistakenly switched at birth. "My siblings joked that, you know, you were the mailman's kid or stuff like that ...

This pathway, or others like it, could explain why some inheritable traits between generations can’t be explained exclusively via DNA and RNA. "There are a lot of traits and disorders that we ...