The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.

It is characterized by the accumulation of cholesteryl esters, macrophages, and fibrous elements in the intimal region underlying the endothelial-cell monolayer.

Rehman, J, Li, J, Parvathaneni, L, et al. Exercise acutely increases circulating endothelial progenitor cells and monocyte-/macrophage-derived angiogenic cells. J Am Coll Cardiol 2004;43:2314-2318 ...

Background: This experiment is designed to investigate the clinical correlation between mesenchymal stem cells, macrophages, endothelial progenitor cells and hepatocellular carcinoma, furthermore to ...

Hongu, T., Pein, M., Insua-Rodríguez, J. et al. Perivascular tenascin C triggers sequential activation of macrophages and endothelial cells to generate a pro-metastatic vascular niche in the lungs.

More information: Xingsheng Ren et al, Macrophage-endothelial cell crosstalk orchestrates neutrophil recruitment in inflamed mucosa, Journal of Clinical Investigation (2023). DOI: 10.1172/JCI170733 ...

These endothelial abnormalities facilitated the accumulation and infiltration of monocytes and macrophages into the intima, where the macrophages exhibited both inflammatory and anti-inflammatory ...

A specific subset of TAMs that produce a protein called Tie2 can also stimulate angiogenesis through secretion of vascular endothelial growth factor (VEGF) and other molecules (2). At the same time, ...

These endothelial abnormalities facilitated the accumulation and infiltration of monocytes and macrophages into the intima, where the macrophages exhibited both inflammatory and anti-inflammatory ...