Several lines of evidence have implicated the actin cytoskeleton in the internalization step of clathrin-mediated endocytosis in various organisms from yeast to mammals. Live-cell imaging studies ...

Clathrin-coated endocytic vesicles are produced by a complex modular protein machinery that transiently assembles on the plasma membrane. This machinery selects and concentrates cargo molecules ...

To analyze the data further, the researchers grouped endocytic events based on the clathrin lifetimes and the models of vesicle formation. This revealed interesting features. "We found that short ...

To analyze the data further, the researchers grouped endocytic events based on the clathrin lifetimes and the models of vesicle formation. This revealed interesting features. “We found that ...

Bergeron-Sandoval constructed a mathematical model to explain precisely how the endocytic condensate forces the membrane to bend into the condensate to form a nascent vesicle. "Our model can be ...

At a critical moment the cell membrane buckles and invaginates into the condensate, ultimately being pinched off to form a spherical vesicle. How membrane buckling occurs has been a mystery, but the ...