Synthetic chemicals and plastics are useful and indispensable in our lives. On the other hand, the world is grappling with ...

Mutations in genes that regulate endocrine signalling pathways can increase the lifespans of worms, flies and mammals. Endocrine pathways might therefore serve as targets for the manipulation of ...

Parabens, widely used preservatives in cosmetics, pharmaceuticals, and food products, have raised significant health concerns ...

Approximately 75% of all breast cancers are ER-positive, and so targeting ER signaling with endocrine therapy has been and continues to be the backbone for the treatment of ER+ breast cancer.

As hormonally-responsive tissues, the breast and thyroid share endocrine signaling. Breast cells are responsive to thyroid hormone signaling and are affected by altered thyroid hormone levels.

The effect of this faulty signaling could be serious and wide-ranging because the endocrine system helps to moderate everything from fertility and reproduction to growth, metabolism, immunity and ...

Endocrine signaling from peripheral systems, such as skeletal muscle, as well as organ systems related to providing the energy of activity, such as the liver and adipose tissue, ...

Response to Endocrine Therapy. Endocrine therapy is the mainstay of treatment for ER+/PR+ breast cancer, by blocking the hormones estrogen and progesterone that feed the tumor.

As recommendations suggest extending hormone-based breast cancer treatment to 10 years for some patients, a new study sheds light on whether patients are opting for it.