(2) These cells are activated using anti-CD3/CD28 antibodies to stimulate their proliferation. (3) Genetic modification of the T cells is performed by inserting the CAR gene, enabling them to ...

A.M. Young and Iain A. McNeish, Centre for Molecular Oncology & Imaging, Institute of Cancer, Barts & The London School of Medicine & Dentistry, Charterhouse Square, London EC1M 6BQ, UK Disclosure ...

recognizes specific tumor antigens through its chimeric antigen receptor (CAR), leading to enhanced phagocytosis of the tumor cells and concomitant presentation of tumor antigen to T cells for their ...

Antigen recognition plays a key role in both the innate and adaptive immune systems. Antigens are small molecular components of cells or non-cellular biological materials. Most often, they are parts ...

We have generated membrane-associated T-cell engager molecules (MATEs) consisting of a CD3 binding domain as well as a Tat-PTD motif to facilitate their attachment to the surface of cells independent ...

Given that wt p53 induces apoptosis in response to adenovirus E1a proteins 12 ... Levine, A.J. Adenovirus Elb-58kDa tumor antigen and SV40 large T antigen are physically associated with the ...

The immune stimulatory effects of radiotherapy can be exploited by concurrent PI3Kγ inhibition to significantly constrain pancreatic cancer growth. Combined radiotherapy and PI3Kγ inhibition stimulate ...

We work right across the cancer research pathway with strengths ranging from cell biology to healthcare research. We aim to nurture the thought leaders of today and tomorrow through the provision of ...

Leveraging their unique structural attributes and facile modification capabilities, VLPs can serve as an effective platform for the delivery of tumor antigens, thereby stimulating the immune system ...

17 Since referral for several cancer types is often contingent on concerning results from a triage test, such as FIT for colorectal cancer or cancer antigen 125 for ovarian cancer, it is plausible ...