The findings suggest that the body's own immune system may be undermining the treatment with gene therapy such as Elevidys (delandistrogene moxeparvovec) aimed at reintroducing the missing protein ...

Laurence Fishburne's absence from "The Matrix: Resurrections" was one of the film's biggest talking points. The movie, which came out in 2021, served as the series' reintroduction to the sci-fi ...

A new article argues dystrophin immunogenicity is an under-examined issue in the treatment of Duchenne muscular dystrophy. The quest to find a permanent solution to Duchenne muscular dystrophy (DMD) ...

A decision on whether to lift the trials’s temorary halt will follow the EU regulatory process. Elevidys is a one-time gene therapy designed to deliver a gene that codes for micro-dystrophin protein, ...

Duchenne muscular dystrophy is caused by the absence of the protein dystrophin. Therapies for DMD, including Elevidys, work to reintroduce dystrophin — but the immune system might perceive ...

The DMD indication in non-ambulatory patients is approved under accelerated approval based on expression of ELEVIDYS micro-dystrophin (noted hereafter as “micro-dystrophin”) in skeletal muscle.

These findings highlight the importance of matrix component interactions in modulating detection sensitivity and show that these effects are critical in allowing clinically relevant detection levels ...

Step 4: p-cMGP is secreted into the extracellular matrix or the circulation to inhibit soft tissue calcification, VSMC (vascular smooth muscle cell) trans-differentiation into OPC (osteochondrogenic ...

Let’s be real — when you think of “The Matrix,” it’s hard not to picture Laurence Fishburne donning those tiny sunglasses and waxing philosophical as the ever-iconic Morpheus.

By McKinley Franklin Laurence Fishburne wanted to be a part of the fourth film in the Matrix franchise, but the team behind the project wasn’t on the same page. “I offered my services to the ...

As a component of the dystrophin-glycoprotein complex DGC ... ultimately lead to significant disruptions in the organization and functional maintenance of the extracellular matrix, as well as in the ...