"It was a ‘eureka’ moment when we found TXA2 was the molecular signal that activates this suppressive effect on T cells ... pathway could be used in new treatments to prevent the cancer ...

We created a suspension culture model of high-grade serous ovarian cancer (HGSOC) dormancy and devised a novel CRISPR screening approach to identify survival genes in this context. In combination with ...

1 Innovation in Precision Medicine Laboratory, Instituto Nacional de Medicina Genómica, Mexico City, México 2 Posgrado en Ciencias Biológicas, Unidad de Posgrado, Circuito de Posgrados, Ciudad ...

2022). Among these potent signaling pathways that mediate CSCs include Wnt, Notch, TGFβ-SMAD, Hh, JAK-STAT, VEGF, IL-8, granulocyte macrophage colony-stimulating factor (GM-CSF), and bone morphogenic ...

LMU researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells. Colorectal cancer is one of the most common types of cancer worldwide.

In normal cells this Wnt signaling pathway is carefully controlled by a gene called APC, which functions to prevent excessive cell growth and tumor formation. However, the majority of colon cancers ...

Therefore, these aberrations in cell signaling pathways are integral to the formation and growth of cancer. Historically, cancer treatments (chemotherapy and radiation therapy) target any cell that is ...

It also maintains stem cells in many tissues in adults: While insufficient Wnt signaling leads to the failure of tissue repair, elevated Wnt signaling may result in cancer,” Yang said. It is very ...

This is certainly the case for the excessive cell growth ... that a well-known signaling pathway helps cancers grow by blocking the pro-growth signals from a second major cancer pathway.

Cancer cells avoid an immune system attack after radiation by commandeering a cell signaling pathway that helps dying cells avoid triggering an immune response, a new study suggests. Cancer cells ...

we discuss the latest developments primarily in important cell signaling pathways regulated by lncRNAs in cancer. Cell signaling plays a pivotal role in a variety of cellular processes in response ...