Its lead product candidate is reproxalap, a reactive aldehyde species (RASP) modulator, which is in Phase III clinical trial for the treatment of dry eye disease and allergic conjunctivitis; and ...

Figure 1: Structures of the Fd–FNR complex and PDR. Figure 3: NMR chemical shift perturbation of Fd upon complex formation with FNR. Figure 4: Structural perturbation of FNR induced by complex ...

NADPH:cytochrome P450 oxidoreductase (POR) is the obligate electron donor for microsomal cytochrome P450 (CYP) enzymes involved in the biosynthesis of endogenous substances like bile acids and other ...

Abbreviations are as defined in text. Figure 2. Summary of role of cholesterol and hypercholesterolemia in hypertension and atherosclerosis. HMG-CoA reductase inhibitors (statins) exert both direct ...