A different, more optimized version of the molecule, called PX578, has been advanced to the clinic. That compound recently entered Phase 1 trials.

Laboratory of Advanced Optoelectronic Materials, Suzhou Key Laboratory of Novel Semiconductor-Optoelectronics Materials and Devices, State and Local Joint Engineering Laboratory for Novel Functional ...

Here we report the cryo-EM structure of ligand-free, G protein-free C3aR, providing insights into its inactive conformation. In addition, we determine the structures of C3aR in complex with the ...

The Icahn School of Medicine at Mount Sinai has launched the AI Small Molecule Drug Discovery Center, a bold endeavor that harnesses artificial intelligence (AI) to revolutionize drug development.

Mol Cancer Ther (2025) 24 (4): 497–510. Murine double minute 2 (MDM2) is an E3 ligase that inhibits the tumor suppressor protein p53. Clinical trials employing small-molecule MDM2/p53 interaction ...

Research suggests that eating carrots can boost eye health—but these gains come with caveats. As John Stolarczyk, curator of the virtual World Carrot Museum, told Smithsonian magazine in 2013 ...

UCLA scientists have developed a molecule, PP405, that may reverse hair loss by reactivating dormant follicles. Early trials show promising results, and more testing is underway, with FDA approval ...

A team of researchers from McMaster University has identified a new molecule – lariocidin – that can challenge some of the most drug-resistant bacteria on Earth. The discovery responds to a critical ...

Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institution, Fudan University, Shanghai 200438, China ...

Chinese scientists have developed a molecule which helps with the "last mile" delivery of antigens in cells and can act as an adjuvant to enhance the effect of vaccines for preventing infectious ...

Wang et al. pursued a fresh approach by instead attaching antigens to a molecule that guides them to a key organelle — the endoplasmic reticulum (ER). This subcellular compartment is where ...