The Flt3L hormone can increase dendritic cell numbers, helping the immune system to fight off cancer and infection. Dr Naik and his team studied developing immune cells at a single cell level to ...

Comparison of intratumoral loading of Flt3L/TK-recruited dendritic cells and systemic vaccination with tumor-lysate loaded dendritic cells in the stringent syngeneic CNS1 rat glioma model: Effect of ...

“Antigen presenting cells, such as dendritic cells (DCs), are essential for effective T cell responses,” explained Dr. Fling. “Flt3 [fms-like tyrosine kinase 3] ligand, a growth factor for DCs, was ...

PURPOSE: To evaluate preoperative dendritic cell (DC) mobilization and tumor infiltration after administration of Flt3 ligand (Flt3L) to patients with metastatic colon cancer. PATIENTS AND METHODS: ...

New oncolytic virus expressing FLT3L enhances antitumor immunity by activating dendritic cells. May 20, 2025. No Comments. Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals ...

As the JMU team reports in the journal Immunity, it is due to a locally acting cytokine, the FLT3 ligand, that the dendritic cells always stay close together during their developmental migration.

LMU researchers have shown that a particular type of immune cell acts more flexibly than previously thought—with the potential for new therapeutic approaches.

CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer. Cell Reports Medicine , 2024; 101479 DOI: 10.1016/j.xcrm.2024.101479 Cite This ...