Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA ...

1UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA.

Mouse whole-lung RNA was prepared using TRIzol (Invitrogen, Carlsbad, CA). Flow sorted cells RNA was extracted using the RNeasy Plus Micro Kit (Qiagen, Germantown, MD). Gene mRNA expression (Flt3, ...

There have been reports of sympathetic and parasympathetic fibers innervating dendritic cells (DCs) in the spleen (22 ... with increased expression of FLT3L and larger fractions of CD11c+ cells ...

We have known for decades that dendritic cell numbers increase in response to a hormone called Flt3L. But exactly how Flt3L spurs production has remained unclear. Now, thanks to new research from ...

相关研究结果于2020年5月18日在线发表在Nature Immunology期刊上，论文标题为“Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity”。 图片来源：CC0 ...

FLT3L (Fms-like tyrosine kinase 3 ligand) is an endogenous factor that stimulates the differentiation of migratory and lymph node-resident classical DCs. 20 While these animals are healthy at baseline ...

Rationale Dendritic cells (DC) accumulate in the lungs of patients with idiopathic lung fibrosis, but their pathogenetic relevance is poorly defined. Objectives To assess the role of the FMS-like ...