7月29日，国际学术期刊Mucosal Immunology在线发表了中国科学院上海生命科学研究院生物化学与细胞生物学研究所陈剑峰研究组的最新研究成果Regulatory T-cell depletion in the gut caused by integrin β7 deficiency exacerbates DSS colitis by evoking aberrant innate ...

本研究针对炎症性肠病(IBD)治疗需求，首次分离鉴定黄连来源的细胞外囊泡样纳米颗粒(Cc-ELNs)，发现其通过递送miR-5106靶向Slc39a2锌转运蛋白，恢复中性粒细胞内锌稳态，显著抑制中性粒细胞胞外诱捕网(NETs)形成，从而缓解DSS诱导的小鼠结肠炎。该研究为植物源性 ...

To their surprise, they found that the mice lacking DCIR showed reduced colitis severity and AOM-DSS-induced colorectal tumor growth. Moreover, compared to the wild-type mice (control), the DCIR ...

Researchers from Ocean University of China and Qingdao Marine Science and Technology Center published data from a preclinical study that investigated the impact of the quinazolinone derivative MR-2938 ...

Researchers from Chinese Academy of Sciences detailed the creation of a new dextran sulfate sodium (DSS)-based mouse model of immune checkpoint blockade (ICB) therapy-associated colitis. BioWorld ...

Furthermore, when Axin1 ΔIEC and Axin1 ΔPC mice were cohoused with control mice, they became more susceptible to dextran sulfate sodium (DSS)-colitis, suggesting the protective role of Axin1 in ...

The Markowitz laboratory previously showed that inhibition of 15-PGDH, which enzymatically degrades prostaglandin PGE2, results in increased levels of tissue PGE2 and sustained colonocyte ...