Researchers demonstrated how Mycobacterium tuberculosis modifies its DNA and regulates both replication and gene activity through a reversible process known as ADP-ribosylation. This is the first ...

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot. These knots can ...

Here, the authors employ CRISPR-Cas9 nickase to target cancer-associated focal gene amplifications to selectively kill cancer cells through the production of DNA replication-associated double ...

Institut für Pharmazie, Martin-Luther-Universität Halle−Wittenberg, Halle, Germany, Kurt−Mothes−Str. 3, 06120 Halle (Saale), Germany ...

The asymmetric diazoamines 1-(2-chlorophenyl)-3-(4-carboxyphenyl)triazene (1), 1-(2-fluorophenyl)-3-(4-carboxyphenyl)triazene (2) and 1-(2-fluorophenyl)-3-(4-amidophenyl)triazene (3) were evaluated ...

The mitochondrial genome is the full genetic complement of a mitochondrion. Mitochondrial DNA is only a small portion of the total DNA of a eukaryotic cell and in most species is solely inherited ...