Can we exploit the DNA repair pathways in cancer cells to increase the efficacy of existing and future cancer treatments? This Review discusses the current state of play. DNA repair pathways can ...

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

DNA damage response, or DDR for short, is the technical term for this. Specific signaling pathways usually initiate the immediate recognition and repair of DNA damage, thus ensuring the survival ...

In such cases, DNA repair pathways - such a vital physiological process in normal life - can be hijacked by cancer cells who use them to resist the effects of chemotherapy drugs.

A study reveals significant genomic differences in metastatic prostate cancer among veterans, highlighting the need for ...

Drs Olga Brieieva and Martin Higgs discuss in vitro genomic models for predicting clinical resistance to PARP inhibitors for ...

Homologous recombination (HR) is one of the key DNA repair pathways in cells. It is essential for repairing double-stranded breaks in DNA and for DNA crossover events during sexual reproduction.

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

You may have seen it in the news recently: a baby in Pennsylvania with a rare genetic disorder was healed with a personalized treatment that repaired ...

T cells are the immune system’s frontline fighters. When they detect danger, they rapidly multiply and transform into effector cells that destroy pathogens.