Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

Homologous recombination (HR) is one of the key DNA repair pathways in cells. It is essential for repairing double-stranded breaks in DNA and for DNA crossover events during sexual reproduction.

A new hereditary condition has been discovered that affects patients' ability to repair DNA—leaving them both at greater risk ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk of ...

To investigate how plants control EGT, the team focused on the DSB repair pathways — known entry points for organellar DNA. Using genetically engineered tobacco plants and a previously developed ...

DNA damage response articles from across Nature Portfolio. Atom; RSS Feed; Definition. The DNA damage response is a network of cellular pathways that sense, signal and repair DNA lesions.

The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD) testing ...

Background: DNA repair deficiency is common among tumors, and emerging data suggest that genomic instability is associated with response to immuno-oncology (IO) therapies (PMID 28630051). We evaluated ...

A new hereditary condition has been discovered that affects patients' ability to repair DNA – leaving them both at greater ...