Can we exploit the DNA repair pathways in cancer cells to increase the efficacy of existing and future cancer treatments? This Review discusses the current state of play. DNA repair pathways can ...

However, our bodies have dedicated enzymes and pathways which can repair our broken DNA back together through several different mechanisms, known as DNA repair pathways. Some cancers, however, can ...

“DNA damage response pathways cause replication forks to slow down progression by about ten-fold. This ten-fold slowdown means that synthesis of the cell’s genome, which usually takes about 12 hours, ...

The Role of DNA Repair Pathways in Antibody Somatic Hypermutation. 11h. In a recent online publication in SCIENCE CHINA Life Sciences, ... (BER) or mismatch repair (MMR) pathways, ...

image: DSB repair by SMARCAD1, MSH2, and EXO1. view more Credit: Institute for Basic Science. DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes.

"We found that the manner in which tumor cells die after radiotherapy depends on the engagement of specific DNA repair ...

“In one particular DNA repair pathway, it takes about 30 proteins to go from finding the pothole to putting in the repair patch. While we can’t observe all of these proteins at once, ...

Precision gene editing is crucial for treating genetic diseases, as it enables targeted correction of specific mutations. A ...

Published online May 16 in the journal Cell, the report describes the molecular mechanism behind a DNA repair pathway that counters the mistaken inclusion of a certain type of molecular building ...

DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic ...