Beyond the ladder-like structure described above, another key characteristic of double-stranded DNA is its unique three-dimensional shape. The first photographic evidence of this shape was ...

A recent study has identified a triple stranded HIV cDNA intermediate of reverse transcription, or a ‘central DNA flap,’ as a component of HIV nuclear import. The retroviral replication cycle ...

The pegRNA binds to a matching sequence on the target DNA strand. The Cas9 nickase cuts the unbound complementary strand, creating a flap. The dangling DNA flap binds to a matching sequence on the ...