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Study identifies promising target for treating inflammatory bowel disease and colitis-induced colorectal cancers
More information: Xingchen Dong et al, Farnesoid X receptor mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression, JCI Insight (2024). DOI: 10.1172/jci.insight.
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Tiny algae-made robots treat inflammatory bowel disease without drug
In IDB, macrophages, a type of immune cell begins ... to complete a successful journey to the human colon, it would have to survive the acidity of the stomach. So they engineered a pH coating ...
gut.bmj17d
Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control
Background The immune suppression mechanisms in pancreatic ductal adenocarcinoma (PDAC) remain unknown, but preclinical ...
Nature4y
Carisma drives CAR-M engineered macrophage cancer therapy forward
To overcome these hurdles, Carisma has developed CAR-M, leveraging the natural role of macrophages to initiate ... metastatic lung, ovarian, colon and bladder cancers), for which there are no ...