Chymase is a serine protease that has been studied as a drug target in inflammatory diseases, so far with limited success. Fulacimstat is a novel drug candidate inhibiting chymase that has been ...

Chymase concentrations in supernatants of HSMCs were measured by DuoSet™ ELISA (R&D Systems, Minneapolis, MN, USA). The ELISA detection range was 100-8,000 pg/ml). IL-4 and IL-13 concentrations were ...