Gout flares are associated with cardiovascular events. Treating gout to target serum urate levels prevents flares, but ...

The European Alliance of Associations for Rheumatology - recommends that serum urate should be maintained at <6 mg/dL (360 ...

Gout flares are associated with cardiovascular events. Treating gout to target serum urate level prevents flares, but whether such treatment can also ...

A swollen toe is a key sign of gout, a type of arthritis. But your ankle is at risk too. Here's what gout symptoms in an ankle look like and the treatments that you can try.

Patients with confirmed tophi and more frequent acute gout attacks ... patients who reported symptoms of inadequately controlled chronic gout (similar to refractory chronic gout), defined here ...

Mechanisms of chronic tophaceous gout. Neutrophil granulocytes ingest needle-shaped MSU crystals (yellow). During low concentrations of neutrophils, this process releases cytokines (red dots) and ...

Tophi are firm, painless yellow lesions that form in and around the joints in people with advanced gout. They have a uric acid (monosodium urate) core, and the skin that covers them can become ...

The Food and Drug Administration (FDA) has granted Fast Track designation to AR882 for the treatment of clinically visible tophi in patients with gout. AR882 is an investigational selective uric ...

AR882 is an investigational selective uric acid transporter 1 inhibitor. The Food and Drug Administration (FDA) has granted Fast Track designation to AR882 for the treatment of clinically visible ...

Clinicians need systematic approaches to treatment-refractory gouty arthritis and tophaceous disease (particularly with erosive, destructive chronic arthritis), including strategies to tackle ...

If uric acid levels remain uncontrolled during the early stages, gout may progress and become chronic. Chronic tophaceous gout is characterized by tophi, an accumulation of urate crystals that appear ...

There are only a few case reports that are published so far, indicating that there is increased production of calcitriol in patients with chronic tophaceous gout similar to the mechanism that ...