A long-standing question has been to understand which of the many ribosomal RNA clusters are expressed and how they are regulated. Here the authors characterize a new, noncoding RNA SNUL-1 and propose ...

Their findings, which redefine the roles of the X and Y chromosomes, suggest these chromosomes are crucial regulators of gene expression beyond just determining sex. Credit: SciTechDaily.com A ...

Such gene therapies introduce a functional gene to establish a continuous endogenous expression of factor VIII or factor IX and offer the potential for a lifetime treatment for haemophilia patients. F ...

Copies of the same gene can appear on different chromosomes, boosting the survivability of humans as a species. Each gene is responsible for different functions. For example, some tell cells how ...

(2004) suggested that this phenomenon probably reflects the level of expression of the β-like globin gene cluster. These observations seem to indicate that active genes might be found not only on the ...

An important player in the healthy development of female embryos turns out also to play a key role in regulating the behavior of chromosome loops and gene expression in both sexes, according to a ...

Chromosomes occupy specific regions of the cell nucleus called chromosome territories ... and was directly related to the regulation of gene expression. “We have demonstrated that the ...

Chromosome territory (CT) organization and chromatin condensation have been linked to gene expression. Although individual genes can be transcribed from inside CTs, some regions that have ...

Dosage compensation mechanisms that reduce X chromosome expression in females cause sex chromosomes to have lower gene expression than non-sex chromosomes. Modern sex chromosomes evolved from a pair ...

By the comparative analyses on the global transcript profiles with the euploid donor, genome-wide alterations in gene expression were revealed in two aneuploids, and their majority of differentially ...