This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...
This important study reveals a role for IκBα in the regulation of embryonic stem cell pluripotency. The solid data in mouse embryonic stem cells include separation of function mutations in IκBα to ...
Experimental approaches will include chromatin immunoprecipitation assays and immunofluorescence to examine the level of histones and the appearance of DNA damage markers at telomeres. Does binding of ...
The chromatin landscape is a key aspect of epigenetic regulation in eukaryotes. Old histones are recycled during DNA replication, therefore providing a blueprint for the duplication of their ...
Click here to download 'A solid phase chromatin immunoprecipitation assay (ChIP)' brochure The kits have been optimised for 1000 ng sample sizes, which allows for better results from smaller ...
The structure of chromatin is critical for many aspects of cellular physiology and is considered to be the primary medium to store epigenetic information. The nucleosomes together with the non-histone ...
To verify the performance and specificity of Thermo Scientific antibodies, we have created a comprehensive workflow to assess antibody specificity using immunoprecipitation combined with mass ...