本综述深入探讨了缺氧（Hypoxia）、肿瘤干细胞特性（Cancer Cell Stemness）与药物耐受性（Drug Resistance）之间的复杂关系，揭示了其在肿瘤治疗中的关键作用。 肿瘤微环境中的缺氧是实体瘤的常见特征，与肿瘤的侵袭性、复发和治疗耐受性密切相关。缺氧能够诱导 ...

Hypoxia-driven gene and protein changes enhance epithelial-to-mesenchymal transition, remodel the extracellular matrix, drive drug resistance, support cancer stem cells and aid evasion from immune ...

Hypoxia, when cells are deprived of oxygen, is a key feature of cancer and other diseases including arthritis. While it's well-known that oxygen deprivation changes how cells express DNA ...

For instance, why do Schwann cells have such a mechanism? One possible explanation could be related to the lack of oxygen, so-called hypoxia, after an injury. In this case, hypoxia promotes the ...

resulting in an impaired ARG1 expression and immunosuppression of hypoxic CD71 + neutrophils, without negatively affecting other immune cells. By combining isosafrole treatment with a targeted ...